All Original Research
-
55. Killarney, S.T.; Mesa, G.; Washart, R.; Mayro, B.; Dillon, K; Wardell, S.E.; Newlin, M.; Lu, M.; Abu Rmaileh, A.; Liu, N.; McDonnell, D.P.; Pendergast, A.M.; Wood, K.C.* (2024). PKN2 is a dependency of the mesenchymal-like cancer cell state, Cancer Discovery (In press).
-
54. Bhowmik, P.K.*; King, D.; Chen, S.L.; Principe, R.C.G.; Han, H.; Evlyukhin, E.; Cifligu, P.; Jubair, A.; Kartazaev, V.; Gayen, S.K.; Killarney, S.T.; Caci, J.D.; Wood, K.C. (2024). Synthesis, optical spectroscopy, and laser and biomedical imaging application potential of 2,4,6-triphenylpyrylium tetrachloroferrate and its derivatives, J. Phys. Chem. B 128, 9815-9828. [Pubmed][PDF]
-
53. Kelly, L.M.¶; Rutter, J.C.¶; Lin, K.H.¶; Ling, F.; Pasquer, H.; Nhat, D.H.; Namor, F.; Killarney, S.T.; Ang, H.X.; Arang, N.; Lombard, B.; Loew, D.; Brunel, L.; Carretero, E.; Verdie, P.; Amblard, M.; Fodil, S.; Huynh, T.; Sebert, M.; Ades, L.; Raffoux, E.; Fenouille, N.; Itzykson, R.; Forget, A.; Lobry, C.; Benajiba, L.; Martin, A.R.*; Wood, K.C.*; Puissant, A.* (2024). Targeting a lineage-specific PI3Kg/AKT signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule, Nature Cancer (In press). (¶Co-first authors; *Co-corresponding authors). [Pubmed][PDF]
-
52. Nussbaum, D.N.; Martz, C.A.; Waters, A.M.; Barrera, A.; Rutter, J.C.; Cerda-Smith, C.G.; Stewart, A.E.; Wu, C.; Cakir, M.; Levandowski, C.B.; Kantrowitz, D.E.; McCall, S.J.; Pierobon, M.; Petricoin, E.F.; Smith, J.J.; Reddy, T.E.; Der, C.J.; Taatjes, D.J.; Wood, K.C.* (2024). Mediator kinase inhibition impedes transcriptional plasticity and prevents resistance to ERK/MAPK targeted therapy in KRAS mutant cancers, npj Precision Oncology (In press). [PDF]
-
51. Gilmer, T. M.; Lai, C. H.; Guo, K.; Deland, K.; Ashcraft, K. A.; Stewart, A. E.; Wang, Y.; Fu, J.; Wood, K. C.; Kirsch, D. G.; Kastan, M. B. (2024). A novel dual ATM/DNA-PK inhibitor, XRD-0394, potently radiosensitizes and potentiates PARP and topoisomerase I inhibitors. Molecular Cancer Therapeutics (In press). [Pubmed][PDF]
-
50. Maltas, J.¶; Killarney, S.T.¶; Singleton, K.R.¶; Strobl, M.A.R.; Washart, R.; Wood, K.C.*; Wood, K.B.* (2024). Drug dependence in cancer is exploitable by optimally constructed treatment holidays, Nature Ecology & Evolution 8, 147-162. (¶Co-first authors; *Co-corresponding authors). [Pubmed][PDF]
-
48. Ang, H.X.; Sutiman, N.; Deng, X.L.; Liu, A.; Cerda-Smith, C.G.; Hutchinson, H.M.; Kim, H.; Bartelt, L.C.; Chen, Q.; Barrera, A.; Lin, J.; Shen, Z.; McDowell, I.C.; Reddy, T.E.; Nicchitta, C.V.*; Wood, K.C.* (2023). Cooperative regulation of coupled oncoprotein synthesis and stability in triple-negative breast cancer by EGFR and CDK12/13, Proc. Natl. Acad. Sci. USA 120, e2221448120 (*Co-corresponding authors).) [Pubmed][PDF]
-
47. Mayro, B.; Hoj, J.P.; Cerda-Smith, C.G.; Hutchinson, H.M.; Caminear, M.W.; Thrash, H.L.; Winter, P.S.; Wardell, S.E.; McDonnell, D.P.; Wu, C.; Wood, K.C.; Pendergast, A.M.* (2023). ABL kinases regulate the stabilization of HIF-1a and MYC through CPSF1, Proc. Natl. Acad. Sci. USA 120, e2210418120. [Pubmed] [PDF]
-
45. Lidsky, M.E. ¶,*; Wang, Z.¶; Lu, M.; Liu, A.; Hsu, S.D.; McCall, S.J.; Sheng, Z.; Granek, J.A.; Owzar, K.; Anderson, K.S.; Wood, K.C.* (2022). Leveraging unique patient-derived models of FGFR2 fusion-positive intrahepatic cholangiocarcinoma to identify novel synergistic therapies, npj Precision Oncology 6, 75. [Pubmed][PDF] (¶Co-first authors; *Co-corresponding authors).
-
44. Kishton, R.J.*; Patel, S.J.; Decker, A.E.; Vodnala, S.K.; Cam, M.; Yamamoto, T.N.; Patel, Y.; Sukumar, M.; Yu, Z.; Ji, M.; Henning, A.N.; Gurusamy, D.; Palmer, D.C.; Stefanescu, R.A.; Girvin, A.T.; Lo, W.; Pasetto, A.; Malekzadeh, P.; Deniger, D.C.; Wood, K.C.; Sanjana, N.E.; Restifo, N.P.* (2022). Cancer genes disfavoring T cell immunity identified via integrated systems approach, Cell Reports 40, 111153. [Pubmed][PDF]
-
43. Lin, K.H.¶; Rutter, J.C.¶; Xie, A.; Killarney, S.T.; Vaganay, C.; Benaksas, C.; Ling, F.; Sodaro, G.; Meslin, P.A.; Bassil, C.F.; Fenouille, N.; Hoj, J.P.; Washart, R.; Ang, H.X.; Cerda-Smith, C.G.; Chaintreuil, P.; Jacquel, A.; Auberger, P.; Forget, A.; Itzykson, R.; Lu, M.; Lin, J.; Pierobon, M.; Sheng, Z.; Li, X.; Chilkoti, A.; Owzar, K.; Rizzieri, D.A.; Pardee, T.S.; Benajiba, L.; Petricoin, E.; Puissant, A.*; Wood, K.C.* (2022). P2RY2-AKT activation is a critical actionable consequence of nuclear export inhibition in acute myeloid leukemia, Nature Cancer 3, 837-851. (¶Co-first authors; *Co-corresponding authors). [Pubmed][PDF]
-
42. Ali, M.; Lu, M.; Ang., H.X.; Soderquist, R.S.; Eyler, C.E.; Hutchinson, H.M.; Glass, C.; Bassil, C.F.; Lopez, O.M.; Kerr, D.L.; Falcon, C.J.; Yu, H.A.; Hata, A.N.; Blakely, C.M.; McCoach, C.E.; Bivona, T.G.; Wood, K.C. (2022). Small molecule targeted therapies induce dependence on DNA double-strand break repair in residual tumor cells, Science Translational Medicine 14, eabc7480. [Pubmed][PDF]
-
40. Javaid, S.; Schaefer, A.; Goodwin, C.M.; Nguyen, V.V.; Massey, F.L.; Pierobon, M.; Gambrell-Sanders, D.; Waters, A.M.; Lambert, K.N.; Hobbs, A.G.; Huynh, M.V.; Wood, K.C.; Petricoin, E.F.; Der, C.J.; Cox, A.D.* (2022). Concurrent ERK inhibition blocks farnesyltransferase inhibitor-induced epithelial-to-mesenchymal transition to suppress the growth of HRAS mutant head and neck squamous cell carcinoma, Mol. Cancer Ther. (In press). [Pubmed][PDF]
-
39. Garcia, N.; Del Pozo, V.; Yohe, M.E.; Goodwin, C.M.; Shackleford, T.J.; Wang, L.; Baxi, K.; Chen, Y.; Rogojina, A.T.; Zimmerman, S.M.; Peer, C.J.; Figg, W.D.; Ignatius, M.S.; Wood, K.C.; Houghton, P.J.; Vaseva, A.V.* (2021). Vertical inhibition of the RAF-MEK-ERK cascade induces myogenic differentiation, apoptosis, and tumor regression in H/NRAS Q61X-mutant rhabdomyosarcoma, Mol. Cancer Ther. (In press). [Pubmed][PDF]
-
37. Yellen, B.B.*; Zawistowski, J.S.; Czech, E.A.; Sanford, C.I.; SoRelle, E.D.; Luftig, M.A.; Forbes, Z.G.; Wood, K.C.*; Hammerbacher, J.* (2021) Massively parallel quantification of phenotypic heterogeneity in single cell drug responses, Science Advances 7, eabf9840. (*Co-corresponding authors) [Pubmed][PDF]
-
36. Joh, D.Y.¶; Heggestad, J.T.¶; Zhang, S.¶; Anderson, G.R.; Bhattacharyya, J.; Wardell, S.E.; Wall, S.A.; Cheng, A.B.; Albarghouthi, F.; Liu, J.; Oshima, S.; Hucknall, A.M.; Hyslop; Hall, A.H.S.; Wood, K.C.; Hwang, E.S.; Strickland, K.C.; Wei, Q.*; Chilkoti, A.* (2021) Cellphone enabled point-of-care assessment of breast tumor cytology and molecular HER2 expression from fine-needle aspirates, npj Breast Cancer (In press) (¶Co-first authors; *Co-senior authors).
-
35. Su, A.¶; Ling, F.¶; Vaganay, C.; Sodaro, G.; Benaksas, C.; Del Bello, R.; Forget, A.; Benajiba, L.; Pardieu, B.; Lin, K.H.; Rutter, J.C.; Bassil, C.F.; Fortin, G.; Pasanisi, J.; Antony-Debre, I.; Alexe, G.; Benoist, J.-F.; Pruvost, A.; Pikman, Y.; Qi, J.; Schlageter, M.H.; Micol, J.B.; Roti, G.; Cluzeau, T.; Dombret, H.; Preudhomme, C.; Fenouille, N.; Golan, H.M.; Stegmaier, K.; Lobry, C.*; Wood, K.C.*; Itzykson, R.*; Puissant, A.* (2020). The folate cycle enzyme MTHFR is a critical regulator of cell response to MYC-targeting therapies, Cancer Discovery 10, 1894-1911. (¶Co-first authors; *Co-senior authors) [Pubmed][PDF]
-
34. Ozkan-Dagliyan, I.; Diehl, J.N.; George, S.D.; Schaefer, A.; Papke, B.; Klotz-Noack, K.; Waters, A.M.; Goodwin, C.M.; Gautam, P.; Pierobon, M.; Peng, S.; Gilbert, T.S.K.; Lin, K.H.; Dagliyan, O.; Wennerberg, K.; Petricoin, E.F.; Tran, N.L.; Bhagwat, S.V.; Tiu, R.V.; Peng, S.B.; Herring, L.E.; Graves, L.M.; Sers, C.; Wood, K.C.; Cox, A.D.; Der, C.J. (2020). Low-dose vertical inhibition of the RAF-MEK-ERK cascade causes apoptotic death of KRAS mutant cancers, Cell Reports 31, 107764. [PDF][Pubmed]
-
33. Lin, K.H.¶; Rutter, J.C.¶; Xie, A.; Pardieu, B.; Winn. E.T.; Dal Bello, R.; Forget, A.; Itzykson, R.; Ahn, Y.-R.; Dai, Z.; Sobhan, R.T.; Anderson, G.R.; Singleton, K.R.; Decker, A.E.; Winter, P.S.; Locasale, J.W.; Crawford, L.; Puissant, A.*; Wood, K.C.* (2020). Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer, Nature Genetics 52, 408-417. (¶co-first authors; *co-corresponding authors) [PDF][Pubmed]
-
31. Manzari, M.T.; Anderson, G.R.; Lin, K.H.; Soderquist, R.S.; Cakir, M.; Zhang, M.; Moore, C.E.; Skelton, R.N.; Fevre, M.; Li, X.; Bellucci, J.J.; Wardell, S.E.; Costa, S.A.; Wood, K.C.*; Chilkoti, A.* (2019). Genomically informed small molecule drugs overcome resistance to a sustained release formulation of an engineered death receptor agonist in patient-derived tumor models, Science Advances 5, eaaw9162. (*Co-corresponding authors) [PDF][Pubmed]
-
28. Armstrong, A.J.; Gupta, S.; Healy, P.; Kemeny, G.; Leith, L.; Zalutsky, M.R.; Spritzer, C.; Davies, C.; Rothwell, C.J.; Ware, K.E.; Somarelli, J.; Wood, K.; Riber, T.; Giannakakou, P.; Zhang, J.; Gerber, D.; Anand, M.; Foo, W.-C.; Halabi, S.; Gregory, S.G.; George, D.J. (2019) Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer, PLoS ONE 14, e0216934. [PDF][Pubmed]
-
27. Lin, K.H.¶; Xie, A.¶; Rutter, J.C.; Ahn, Y.; Lloyd-Cowden, J.M.; Nichols, A.G.; Soderquist, R.S.; Koves, T.R.; Muoio, D.; MacIver, N.J.; Lamba, J.; Pardee, T.S.; McCall, C.M.; Rizzieri, D.A.; Wood, K.C. (2019). Systematic dissection of the metabolic-apoptotic interface in AML reveals heme biosynthesis to be a regulator of drug sensitivity, Cell Metabolism 29, 1217. (¶Co-first authors; journal cover article) [PDF][Pubmed]
-
26. Ding, Y.; Huang, D.; Chen, R.; Gong, C.; Sui, P.; Lin, K.H.; Yuan, L.; Xiang, H.; Chen, J.; Yin, T.; Wang, Q.F.; Alexander, P.D.; Song, E.W.; Li, Q.-J.; Wood, K.C.*; Wang, X.F.* (2018). Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers, Nature Communications 9, 4274. (*Co-corresponding authors) [PDF][Pubmed]
-
21. Singleton, K.R.¶; Crawford, L.¶; Tsui, E.; Manchester, H.E.; Maertens, O.; Liu, X.; Liberti, M.V.; Magpusao, A.N.; Stein, E.M.; Tingley, J.P.; Frederick, D.T.; Boland, G.M.; Flaherty, K.T.; McCall, S.J.; Krepler, C.; Sproesser, K.; Herlyn, M.; Adams, D.J.; Locasale, J.W.; Cichowski, K.; Mukherjee, S.; Wood, K.C. (2017). Melanoma therapeutic strategies that select against resistance by exploiting MYC-driven evolutionary convergence, Cell Reports 21, 2796-2812. (¶Co-first authors) [PDF][Pubmed]
-
20. Anderson, G.R.¶; Winter, P.S.¶; Lin, K.H.; Nussbaum, D.P.; Cakir, M.; Stein, E.M.; Soderquist, R.; Crawford, L.; Leeds, J.C.; Newcomb, R.; Stepp, P.; Yip, C.; Wardell, S.E.; Tingley, J.P.; Ali, M.; Xu, M.; Ryan, M.; McCall, S.J.; McRee, A.; Counter, C.M.; Der, C.J.; Wood, K.C. (2017). A landscape of therapeutic cooperativity in KRAS mutant cancers reveals principles for controlling tumor evolution, Cell Reports 20, 999-1015. (¶Co-first authors) [PDF][Pubmed]
-
19. Ali, M.¶; Kaltenbrun, E.¶; Anderson, G.R.¥; Stephens, S.J.¥; Arena, S.; Bardelli, A.; Counter, C.M.*; Wood, K.C.* (2017). Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance, Nature Communications 8, 15617. (¶Co-first authors, ¥Co-second authors, *Corresponding authors) [PDF] [PubMed]
-
18. Price, A.M.; Dai, J.; Bazot, Q.; Patel, L.; Nikitin, P.A.; Djavadian, R.; Winter, P.S.; Salinas, C.A.; Perkins Barry, A.; Wood, K.C.; Johannsen, E.C.; Letai, A.; Allday, M.J.; Luftig, M.A. (2017). Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection, eLife 6, e22509. [PDF][Pubmed]
-
17. Anderson, G.R.; Wardell, S.E.; Cakir, M.; Crawford, L.; Leeds, J.C.; Nussbaum, D.N.; Shankar, P.S.; Soderquist, R.S.; Stein, E.M.; Tingley, J.P.; Winter, P.S.; Zeiser-Misenheimer, E.K.; Alley, H.M.; Yllanes, A.; Haney, V.; Blackwell, K.L.; McCall, S.J.; McDonnell, D.P.; Wood, K.C. (2016). PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation, Science Translational Medicine 8, 369ra175. [PDF][Pubmed]
-
15. Cribb, J.; Osborne, L.D.; Beicker, K.; Psioda, M.; Chen, J.; O’Brien, E.T.; Taylor II, R.M.; Vicci, L.; Hsiao, J.P.L.; Shao, C.; Falvo, M.; Ibrahim, J.G.; Wood, K.C.; Blobe, G.C.; Superfine, R. (2016). An Automated High-throughput Array Microscope for Cancer Cell Mechanics, Sci. Rep. 6, 27371. [PDF][Pubmed]
-
14. Park, S.; Chang, C.; Safi, R.; Liu, X.; Baldi, R.; Jasper, J.; Anderson, G.; Liu, T.; Rathmell, J.; Dewhirst, M.W.; Wood, K.C.; Locasale, J.W.; McDonnell, D.P. (2016). ERRα regulated lactate metabolism contributes to resistance to targeted therapies in breast cancer, Cell Reports 15(2), 323-335. [PDF][Pubmed]
-
12. Misale, S.; Bozic, I.; Tong, J.; Peraza-Penton, A.; Lallo, A.; Baldi, F.; Lin, K.H.; Di Nicolantonio, F.; Nowak, M.A.; Zhang, L.; Wood, K.C.; Bardelli, A. (2015). Vertical suppression of the EGFR pathway delays onset of resistance in colorectal cancer models, Nature Communications 6, 8305-14. [PDF] [Pubmed]
-
11. Martz, C.A.¶; Ottina, K.A.¶; Singleton, K.S.¶; Jasper, J.S.; Wardell, S.E.; Peraza-Penton, A.; Anderson, G.R.; Winter, P.S.; Wang, T.; Alley, H.M.; Kwong, L.N.; Cooper, Z.A.; Tetzlaff, M.; Chen, P.-L.; Rathmell, J.C.; Flaherty, K.T.; Wargo, J.A.; McDonnell, D.M.; Sabatini, D. M.*; Wood, K.C.* (2014). Systematic identification of signaling pathways with potential to confer anticancer drug resistance, Science Signaling 7, ra121. (¶Co-first authors, *Co-corresponding authors; journal cover article) [PDF] [Pubmed] [Podcast]
-
9. Gerriets, V.A.; Kishton, R.J.; Nichols, A.G.; Macintyre, A.N.; Inoue, M.; Ilkayeva, O.; Winter, P.S.; Wood, K.C.; Liu, X.; Priyadharshini, B.; Slawinska, M.E.; Haeberli, L.; Huck, C.; Turka, L.A.; Hale, L.P.; Smith, P.A.; Schneider, M.A.; MacIver, N.J.; Locasale, J.W.; Newgard, C.B.; Shinohara, M.L.; Rathmell, J.C. (2014). Metabolic Programming and PDHK1 Control CD4 T-Cell Subsets and Inflammation, J. Clin. Inv. 125(1):194-207. [PDF] [Pubmed]
-
7. Wood, K.C.; Konieczkowski, D.J.; Johannessen, C.M.; Boehm, J.S.; Tamayo, P.; Botvinnik, O.B.; Mesirov, J.P.; Hahn, W.C.; Root, D.E.; Garraway, L.A.; Sabatini, D.M. (2012). MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma, Science Signaling 5, rs4 (journal cover article). [Pubmed][PDF]
-
1. Meyer, D.E.; Wood, K.; Bachas, L.G.; Bhattacharyya, D. (2004). Degradation of chlorinated organics by membrane-immobilized nanosized metals, Environ. Prog., 23, 232-242. [PDF]